El-Sayed, H., Mohamed, S., Moustafa, A., Aymn, A. (2022). Regioselective synthesis of N-alkylated 4,6-diaryl-2-oxonicotinonitrile. Bulletin of Faculty of Science, Zagazig University, 2022(3), 59-68. doi: 10.21608/bfszu.2022.139178.1140
Hassan A El-Sayed; Sammar ع Mohamed; Ahmed H. Moustafa; Aya A Aymn. "Regioselective synthesis of N-alkylated 4,6-diaryl-2-oxonicotinonitrile". Bulletin of Faculty of Science, Zagazig University, 2022, 3, 2022, 59-68. doi: 10.21608/bfszu.2022.139178.1140
El-Sayed, H., Mohamed, S., Moustafa, A., Aymn, A. (2022). 'Regioselective synthesis of N-alkylated 4,6-diaryl-2-oxonicotinonitrile', Bulletin of Faculty of Science, Zagazig University, 2022(3), pp. 59-68. doi: 10.21608/bfszu.2022.139178.1140
El-Sayed, H., Mohamed, S., Moustafa, A., Aymn, A. Regioselective synthesis of N-alkylated 4,6-diaryl-2-oxonicotinonitrile. Bulletin of Faculty of Science, Zagazig University, 2022; 2022(3): 59-68. doi: 10.21608/bfszu.2022.139178.1140
Regioselective synthesis of N-alkylated 4,6-diaryl-2-oxonicotinonitrile
1Department of Chemistry, Faculty of Science, Zagazig University,
2الزقازيق
3Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Abstract
In the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectivelyIn the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectively.In the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectively.
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