Therapeutic Potential of Oleuropein and Taurine in Alleviating Tamoxifen-Related Kidney Injury

Diab, Abdel Aziz A; Eldahmy, Samih Ibrahim; Abo-elfotoh Attia, Mai Samir; Ayman, Fadwa; Abo El-enein, Naglaa Ebrahim

doi:10.21608/bfszu.2025.358468.1478

Therapeutic Potential of Oleuropein and Taurine in Alleviating Tamoxifen-Related Kidney Injury

Document Type : Original Article

Authors

¹ Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

² pharmacognosy department,faculty of pharmacy,zagazig university,zagazig,Egypt

³ Zoology department, faculty of science, Zagazig, Egypt

⁴ Zoology Department, Faculty of Science, Zagazig University

10.21608/bfszu.2025.358468.1478

Abstract

ABSTRACT
Background: Antioxidant and plant derived poly-phenolic are used as chemopreventive drugs to alleviate negative effects correlated with drug-induced injuries. Tamoxifen (TAM), chemotherapeutic hormonal drug, is utilized in all stage of breast cancer (BC). Nevertheless, TAM usage for a long time caused side effects such as renal toxicity.
Objective: The present study aimed to investigate the effects of oleuropein (OLE) and taurine (TAU) administration on TAM induced renal dysfunction in male albino rats.
Material and methods: 50 male rats were randomly divided into 5 groups (10 animals each group) as follows; group 1 [control rats], group 2; rats were received orally with TAM (20mg /kg), group 3; rats daily administrated with TAU (100mg /kg) and TAM, group 4; rats orally received with OLE (16mg/kg) and TAM and final group 5; rats daily treated with TAU and OLE in combination with TAM for 30 days. In all groups, serum urea and serum creatinine are measured. Histopathological examination of kidney tissue was done.
Results: TAM rats revealed significantly increased in serum urea and creatinine. On the other hand, OLE or TAU treatment showed significantly reduced in theses parameters, but OLE and TAU together had highly improved compared with other groups and amelioration of kidney histoarchitecture.
Conclusion: oleuropein and taurine combination mitigated the reverse effects of TAM induced renal damages that may be due to their potential antioxidant.

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