Elsarkasi, R., Rabie, G., El-Gazzar, N. (2025). article review on bioactivity of secondary metabolites of endophytic fungi.. Bulletin of Faculty of Science, Zagazig University, 2025(3), 243-251. doi: 10.21608/bfszu.2025.358851.1481
Reem Farouk Elsarkasi; Gamal Hassan Rabie; Nashwa El-Gazzar. "article review on bioactivity of secondary metabolites of endophytic fungi.". Bulletin of Faculty of Science, Zagazig University, 2025, 3, 2025, 243-251. doi: 10.21608/bfszu.2025.358851.1481
Elsarkasi, R., Rabie, G., El-Gazzar, N. (2025). 'article review on bioactivity of secondary metabolites of endophytic fungi.', Bulletin of Faculty of Science, Zagazig University, 2025(3), pp. 243-251. doi: 10.21608/bfszu.2025.358851.1481
Elsarkasi, R., Rabie, G., El-Gazzar, N. article review on bioactivity of secondary metabolites of endophytic fungi.. Bulletin of Faculty of Science, Zagazig University, 2025; 2025(3): 243-251. doi: 10.21608/bfszu.2025.358851.1481
article review on bioactivity of secondary metabolites of endophytic fungi.
1botany and microbiology, faculty of science , zagazig university
2Faculty of Science. Zagazig University
3Botany Department, Faculty of science, zagazig university
Abstract
Endophytic fungi are microorganisms that form symbiotic connections with plants, residing in intercellular and intracellular locations throughout their life cycle. These Fungi have drawn a lot of interest because of their capacity to generate bioactive secondary metabolites with diverse biological activities. These metabolites play essential roles in plant defense, enhancing environmental adaptability, and protecting plants from herbivores and pathogens. Additionally, the endophytic fungi's secondary metabolites exhibit remarkable pharmacological properties, including antimicrobial, anticancer, anti-inflammatory, immunosuppressive, and antioxidant activities. Due to these beneficial properties, bioactive compounds derived from endophytic fungus may find use in a number of fields, particularly in the development of pharmaceuticals like anti-cancer drugs and antibiotics, anthelmintics, , immunosuppressants, and antioxidants. The ongoing research focuses on the identification, isolation, and characterization of these compounds, which are considered valuable for their biomedical applications. Despite the promising results, further Research is required to optimize the production methods of these metabolites and to fully understand their mechanisms of action. Continued exploration of The bioactive substances produced by endophytic fungus holds great promise for the discovery of novel therapeutic substances that might significantly affect medication and biotechnology. In conclusion, endophytic fungi represent an important resource for advancing biomedical investigation and creation of new drug therapies.
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