Simple validated approach to quantify valsartan and sacubitril in medications using liquid chromatography

Document Type : Original Article

Authors

1 Chemistry department, Faculty of science, Zagazig

2 Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

3 Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Abstract

A simple, fast, precise, and accurate RP-LC approach to directly assessing the appropriate dosage forms of sacubitril and valsartan in tablets. The technique separations were made using a BDS octadecyl silane analytical column (4.6 × 250 mm, 5 µm). Acetonitrile was employed as the mobile phase in a filtered and degassed mixture of phosphoric acid and 0.05 M potassium phosphate buffer pH 3.5. The ideal wavelength was 230 nm, the column temperature was about 30°C, and the flow rate was set to about 1.0 mL/min. At retention durations of 7.56 and 13.01 min., respectively, the corresponding linear levels for valsartan (VAL) and sacubitril (SAC) were discovered to be within 7.15–57.20 µg/mL and 6.75–54.00 µg/mL, respectively. The calibration correlations for sacubitril and valsartan are 0.9999 and 0.9997, accordingly. The validation methodology workout complies with the regulations Q2(R2) of the ICH standards. Furthermore, the suggested method was used for evaluation of quality in quantitative testing of valsartan, a medication that blocks angiotensin II receptors (ARB). It works by stopping the body from generating a substance that constricts blood vessels. Thus, valsartan relaxes the cardiovascular arteries. This lowers blood pressure and improves the flow of blood and oxygen through the cardiac muscle. Sacubitril tablets, which are used to treat chronic heart failure in adults to help minimize the risk of deaths and admission to the hospital, can also be used to cure cardiac symptoms in children. Prescription dosage types are used to manage heart disease in people of all ages.

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