Snake Venom: A Natural Anti-Arthritis Product

Document Type : Original Article

Authors

1 zoology department, faculty of science, Zagazig university

2 Physiology departement Faculty of science Zagazig university Egypt

3 Department of physiology Faculty of science Zagazig university Egypt

4 Zoology department, Faculty of science, Zagazig University, Sharkia, Egypt

Abstract

The majority of anti-inflammatory medications used to treat chronic inflammatory joint illnesses can reduce symptoms, but they don't cause a full recovery. Thus, in order to stop the progression of joint inflammatory illnesses, new and more effective medications are required. Because they are abundant in bioactive substances, animal venoms can be useful research instruments. In this investigation Snake venom's potential therapeutic effect in autoimmune disorders, including rheumatoid arthritis, is being explored due to its high production of cytokines that promote inflammation. The study investigated the anti-inflammatory and anti-arthritic effects of Naja haje venom (NHV) in male rats, highlighting its potential as an alternative treatment for arthritis. Thirty adult albino rats were divided into five groups, each with varying doses of rheumatoid arthritis and inflammation. The control group received FCA injections, while the FCA/NHVH and FCA/NHVL groups received intraperitoneal injections of lyophilized NHV and indomethacin for 14 days. The study found that NHV treatment for rheumatoid arthritis showed partial regeneration of cartilage, bone, and synovial in palm and ankle joint compartments, similar to results with indomethacin, suggesting NHV's anti-inflammatory and anti-arthritic properties.

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