Evaluation of Plan Quality Used for Treatment of Multitarget by Stereotactic Radiotherapy (SRT)

Document Type : Original Article

Authors

1 Biophysics Branch-Department of Physics - faculty of science - Zagazig University

2 Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, El-Azhar University, Cairo, Egypt

3 Biophysics, Physics Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Abstract

Purpose: The present study aims to minimize radiation exposure to organs at risk (OARs) while ensuring comprehensive coverage. This research assessed the effectiveness of one and dual-isocenter SRT plans and determine the optimal plan for cases with the maximum planned target volume is 36cc and the distance between two lesions ranging from 4 to 9 cm.
Methods: A group of twenty patients diagnosed with brain metastases were subjected to two distinct methods of stereotactic radiation therapy (SRT) planning: one and dual isocenter. The median distance between the targets in these patients was 6.4 cm. We conducted a quantitative evaluation of the treatment plans using dose-volume metrics parameters such as Conformity Index (CI), heterogeneity index (HI), Confirmation Number (CN), gradient index (GI), gradient distance (GD), and selectivity index calculated and subjected to statistical analysis. Additionally, we assessed the impact on organs at risk (OARs) and examined the dose delivered to the normal brain, specifically evaluating V6, V10, and V12 Gy.
Results: The mean dose of (GTV) for one center ranged from 104 % to 114.6% with a slight difference in dual center ranges from 104% to 111.2%. There was a highly significant difference observed in both the monitor units and treatment time recorded between the two techniques of plans.
Conclusion: This work indicates that there are similarities in the target coverage characteristics and spillage of dose between the one and the dual Plan quality. So, we prefer one center volumetric modulator arc therapy treatment plan for saving treatment time.

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