Gouda, A., elsheikh, R., Mahmoud, M., Abdel Allem, A., El Sayed, A., Ghazy, A., Abdalla, S., Jumaa, N., Elsaify, N., Soliman, N. (2025). Quantitative analytical methods for determination of gemifloxacin mesylate in different matrices: A review. Bulletin of Faculty of Science, Zagazig University, 2025(1), 86-101. doi: 10.21608/bfszu.2024.296119.1397
Ayman A Gouda; Ragaa elsheikh; Moataz S. Mahmoud; Ahmed F Abdel Allem; Ahmed El Sayed; Ahmed Ghazy; Sameh Abdalla; Nessma M. Jumaa; Noha E.M. Elsaify; Nehal S.A. Soliman. "Quantitative analytical methods for determination of gemifloxacin mesylate in different matrices: A review". Bulletin of Faculty of Science, Zagazig University, 2025, 1, 2025, 86-101. doi: 10.21608/bfszu.2024.296119.1397
Gouda, A., elsheikh, R., Mahmoud, M., Abdel Allem, A., El Sayed, A., Ghazy, A., Abdalla, S., Jumaa, N., Elsaify, N., Soliman, N. (2025). 'Quantitative analytical methods for determination of gemifloxacin mesylate in different matrices: A review', Bulletin of Faculty of Science, Zagazig University, 2025(1), pp. 86-101. doi: 10.21608/bfszu.2024.296119.1397
Gouda, A., elsheikh, R., Mahmoud, M., Abdel Allem, A., El Sayed, A., Ghazy, A., Abdalla, S., Jumaa, N., Elsaify, N., Soliman, N. Quantitative analytical methods for determination of gemifloxacin mesylate in different matrices: A review. Bulletin of Faculty of Science, Zagazig University, 2025; 2025(1): 86-101. doi: 10.21608/bfszu.2024.296119.1397
Quantitative analytical methods for determination of gemifloxacin mesylate in different matrices: A review
1Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
3Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
Abstract
Gemifloxacin mesylate (GMF) is a fourth generation fluoroquinolone antibacterial synthetic broad-spectrum agent for oral administration with enhanced affinity for bacterial topoisomerase IV and is being developed for the treatment of respiratory and urinary tract infections. The compound has a broad spectrum of activity against Gram-positive and Gram-negative bacteria. There are different analytical methods available to determine GMF applied in quality control of this medicine in order to ensure its effectiveness and safety. A large number of methodologies including UV-visible spectrophotometry, spectrofluorimetry, high performance liquid chromatography, electrochemical and capillary electrophoresis methods have been developed for the quantitation of GMF in bulk, pharmaceutical, and biological samples. UV-spectrophotometric methods lacked wide linear dynamic ranges and sensitivity. There is some scope for developing methods based on ion-association reactions using many acidic anionic dyes, charge-transfer complexation reactions using substituted p-benzoquinone, polynitro phenols, nitro derivatives, etc., and oxidative coupling reactions involving 3-methyl-2-benzo thiazolinone hydrazone and oxidants like cerium(IV), iron(III), permanganate etc.. This paper will attempt to review several published methodologies and the instrumental conditions, which have been applied to measure GMF and within the last 17 years.
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