El-Mesallamy, A., Alahwany, A., El-zaidy, M., Hussein, S. (2024). Demonstration Of Phenolics Content From Garcinia Cambogia Extract And Evaluation Of Its Cytotoxic Activity. Bulletin of Faculty of Science, Zagazig University, 2024(3), 156-162. doi: 10.21608/bfszu.2024.265996.1360
Amani M.D. El-Mesallamy; Ahmed Khaled Mostafa Mohamed Alahwany; Mohamed Ibrahem Ibrahem Mohamed El-zaidy; Sahar awadallah Mohamed Hussein. "Demonstration Of Phenolics Content From Garcinia Cambogia Extract And Evaluation Of Its Cytotoxic Activity". Bulletin of Faculty of Science, Zagazig University, 2024, 3, 2024, 156-162. doi: 10.21608/bfszu.2024.265996.1360
El-Mesallamy, A., Alahwany, A., El-zaidy, M., Hussein, S. (2024). 'Demonstration Of Phenolics Content From Garcinia Cambogia Extract And Evaluation Of Its Cytotoxic Activity', Bulletin of Faculty of Science, Zagazig University, 2024(3), pp. 156-162. doi: 10.21608/bfszu.2024.265996.1360
El-Mesallamy, A., Alahwany, A., El-zaidy, M., Hussein, S. Demonstration Of Phenolics Content From Garcinia Cambogia Extract And Evaluation Of Its Cytotoxic Activity. Bulletin of Faculty of Science, Zagazig University, 2024; 2024(3): 156-162. doi: 10.21608/bfszu.2024.265996.1360
Demonstration Of Phenolics Content From Garcinia Cambogia Extract And Evaluation Of Its Cytotoxic Activity
1Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
2Department of Phytochemistry and Plant Systematics; National Research Centre, Giza, Egypt
Abstract
Garcinia Cambogia traditionally usually termed kokum butter is used as a medicinal plant. The current study sought to determine the alcoholic extract of Garcinia cambogia leaves'and flavonoid content and total phenolic as well as evaluate the plant's cytotoxic potential. The presence of several sorts of phenolics, flavonoids, tannins, carbohydrates and glycosides were shown by phytochemical screening of the ethanolic extract. The ethanolic extract total phenolic content (TPC) in terms of gallic acid equivalent were (0.48±0.014 mg GAE /g of extract powder), while the total flavonoid content (TFC) in terms of quercetin equivalent were (0.35±0.016 mg QE/g of extract powder). Since phenols and flavonoids are potentially active, we assessed the cytotoxic activity of invitro on various human cell lines, including colon (HCT-116), liver (HEPG-2) and breast (MCF-7) cancer cell lines using doxorubicin as the traditional anticancer drug as reference. The outcomes this show that the ethanol extract of G. cambogia leaves was more effect on breast (MCF-7) cell line than liver (HEPG-2) and colon (HCT-116) cell lines becuase presence of high flavonoids and phenolics content.
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