Demonstration Of Phenolics Content From Garcinia Cambogia Extract And Evaluation Of Its Cytotoxic Activity

Document Type : Original Article

Authors

1 Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

2 Department of Phytochemistry and Plant Systematics; National Research Centre, Giza, Egypt

Abstract

Garcinia Cambogia traditionally usually termed kokum butter is used as a medicinal plant. The current study sought to determine the alcoholic extract of Garcinia cambogia leaves'and flavonoid content and total phenolic as well as evaluate the plant's cytotoxic potential.
The presence of several sorts of phenolics, flavonoids, tannins, carbohydrates and glycosides were shown by phytochemical screening of the ethanolic extract. The ethanolic extract total phenolic content (TPC) in terms of gallic acid equivalent were (0.48±0.014 mg GAE /g of extract powder), while the total flavonoid content (TFC) in terms of quercetin equivalent were (0.35±0.016 mg QE/g of extract powder).
Since phenols and flavonoids are potentially active, we assessed the cytotoxic activity of
invitro on various human cell lines, including colon (HCT-116), liver (HEPG-2) and breast (MCF-7) cancer cell lines using doxorubicin as the traditional anticancer drug as reference. The outcomes this show that the ethanol extract of G. cambogia leaves was more effect on breast (MCF-7) cell line than liver (HEPG-2) and colon (HCT-116) cell lines becuase presence of high flavonoids and phenolics content.

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Bulletin of Faculty of Science, Zagazig University
Volume 2024, Issue 3
October 2024
Pages 156-162

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