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Soliman, N., Eldahmy, S., Hussein, S., Hegazey, F. (2024). The impact effects of Cannabidiol oil on Hepatocellular carcinoma (HCC) induced by dimethylnitrosamine (DENA) in male rats.. Bulletin of Faculty of Science, Zagazig University, 2024(3), 70-73. doi: 10.21608/bfszu.2023.250444.1341
Nabil Abass Soliman; Samih Ibrahim Eldahmy; samia Ahmed Hussein; Fatma Hussein Hegazey. "The impact effects of Cannabidiol oil on Hepatocellular carcinoma (HCC) induced by dimethylnitrosamine (DENA) in male rats.". Bulletin of Faculty of Science, Zagazig University, 2024, 3, 2024, 70-73. doi: 10.21608/bfszu.2023.250444.1341
Soliman, N., Eldahmy, S., Hussein, S., Hegazey, F. (2024). 'The impact effects of Cannabidiol oil on Hepatocellular carcinoma (HCC) induced by dimethylnitrosamine (DENA) in male rats.', Bulletin of Faculty of Science, Zagazig University, 2024(3), pp. 70-73. doi: 10.21608/bfszu.2023.250444.1341
Soliman, N., Eldahmy, S., Hussein, S., Hegazey, F. The impact effects of Cannabidiol oil on Hepatocellular carcinoma (HCC) induced by dimethylnitrosamine (DENA) in male rats.. Bulletin of Faculty of Science, Zagazig University, 2024; 2024(3): 70-73. doi: 10.21608/bfszu.2023.250444.1341

The impact effects of Cannabidiol oil on Hepatocellular carcinoma (HCC) induced by dimethylnitrosamine (DENA) in male rats.

Article 6, Volume 2024, Issue 3, October 2024, Page 70-73  XML PDF (1012.32 K)
Document Type: Original Article
DOI: 10.21608/bfszu.2023.250444.1341
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Authors
Nabil Abass Soliman email 1; Samih Ibrahim Eldahmy2; samia Ahmed Husseinorcid 3; Fatma Hussein Hegazey1
1Physiology departement Faculty of science Zagazig university Egypt
2pharmacognosy department,faculty of pharmacy,zagazig university,zagazig,Egypt
3Assistant prof bioessor of biochemistry facuty of medicine zagazig university
Abstract
ABSTRACT
Background: Hepatocellular carcinoma is the third most common cancer to be fatal (HCC). Binding to the transmembrane receptor Patched 1 (PTCH1) depresses the transmembrane G protein-coupled receptor Smoothened (SMO), hence initiating the hedgehog (HH) signaling pathway. This investigation looked at the potential therapeutic and preventive benefits of cannabidiol oil in adult rats that had been subjected to diethyl nitrosamine (DENA)-induced HCC.
Materials and methodology: Of the fifty rats, five groups of ten male rats each were formed. Group I: The group for references. Group II got DENA IP injections for a duration of 12 weeks. For a duration of 12 weeks, rats in Group III received DENA injections in addition to oral CBD provided every other day at a rate of 0.5 ml/kg body weight. Group IV rats were administered oral CBD every other day for two weeks prior to getting a DENA injection for a duration of 12 weeks. After their prior DENA injection, rats in Group V received oral CBD every other day for two weeks.
An examination of the histology of liver tissue was performed.
In conclusion, the treatment of CBD resulted in a considerable improvement in the histopathological liver tissues of adult male rats with DENA-induced HCC.
Keywords
Keywords: Hepatocellular carcinoma; cannabidiol; dimethylnitrosamine (DENA)
Main Subjects
Basic and applied research of zoology
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