Synthesis and Characterization of Some 5-Bromouracil Metal ion Complexes

Document Type : Original Article

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Chemistry Department, Faculty of Science, Zagazig University

Abstract

A Five new complexes [Mg(BrU)2].8H2O (A), [Sr(BrU)2.(H2O) 2 ] (B),
[Ca(BrU)2(H2O)2].H2O (C), [Pb(BrU)2] (D) and [Hg(BrU)2] (E) were prepared by the
reaction of 5-bromoouracil ligand with MgCl2.6H2O, SrCl2.6H2O, CaCl2.2H2O,
Pb(NO3)2 and HgCl2 salts, respectively. The metal complexes were characterized by
conventional methods through their melting point, molar conductivity, elemental
analysis, IR, UV- Vis., 1 H-NMR analyses. The obtained data indicated that the ligand
undergoes keto ↔ enol tautomerism and behaves as mononegative bidentate donor
and interacts with all metal ions . Thermal analysis indicate that the
complexes degrade,more or less, through three main steps representing the dehdration
of physically absorbed and coordinated water molecules then the decomposition of the
unhydrous species leading to metal oxides as final products. Some of the prepared
complexes were tested against gram positive and gram negative bacteria and fungii
which showed effective activity.
Keywords: 5-Bromoouracil–M2+ Complexes, IR, Thermal Analyses, 1H NMR, antimicrobial
and antifungal activities.

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