Ibrahim, N. (2024). Correlation of the interleukins IL-6 ,IL-8,TNF,IL-12A and IL-12B GENE EXPRESSION LEVELS IN PERIPHERAL BLOOD with CHEMOTHERAPUTIC IMPACT IN NON-HODGKIN LYMPHOMA PATIENTS. Bulletin of Faculty of Science, Zagazig University, 2024(2), 24-33. doi: 10.21608/bfszu.2024.217480.1317
Nagi Ali Ibrahim. "Correlation of the interleukins IL-6 ,IL-8,TNF,IL-12A and IL-12B GENE EXPRESSION LEVELS IN PERIPHERAL BLOOD with CHEMOTHERAPUTIC IMPACT IN NON-HODGKIN LYMPHOMA PATIENTS". Bulletin of Faculty of Science, Zagazig University, 2024, 2, 2024, 24-33. doi: 10.21608/bfszu.2024.217480.1317
Ibrahim, N. (2024). 'Correlation of the interleukins IL-6 ,IL-8,TNF,IL-12A and IL-12B GENE EXPRESSION LEVELS IN PERIPHERAL BLOOD with CHEMOTHERAPUTIC IMPACT IN NON-HODGKIN LYMPHOMA PATIENTS', Bulletin of Faculty of Science, Zagazig University, 2024(2), pp. 24-33. doi: 10.21608/bfszu.2024.217480.1317
Ibrahim, N. Correlation of the interleukins IL-6 ,IL-8,TNF,IL-12A and IL-12B GENE EXPRESSION LEVELS IN PERIPHERAL BLOOD with CHEMOTHERAPUTIC IMPACT IN NON-HODGKIN LYMPHOMA PATIENTS. Bulletin of Faculty of Science, Zagazig University, 2024; 2024(2): 24-33. doi: 10.21608/bfszu.2024.217480.1317
Correlation of the interleukins IL-6 ,IL-8,TNF,IL-12A and IL-12B GENE EXPRESSION LEVELS IN PERIPHERAL BLOOD with CHEMOTHERAPUTIC IMPACT IN NON-HODGKIN LYMPHOMA PATIENTS
Department of zoology,Faculty of science, Zagazig university, Zagazig city , Sharkia governorate
Abstract
Non-Hodgkin Lymphoma (NHL) is a type of cancer develops in the lymphatic tissue. Cytokines are small proteins produced by different immune cells and important in cell signaling . They have Interleukins (ILs) as one of their groups . This study aimed at evaluating the correlation of the interleukins ( IL-6 – IL-8 – TNF –IL-12 A and IL-12B) gene expression levels in peripheral blood with chemotheraputic impact in NHL patients . The most common chemotherapy used for NHL is CHOP, which is a combination of four drugs(Cyclophosphamide, Hydroxydaunorubicin called doxorubicin, Oncovin called vincristine, and Prednisolone) . Twenty adult males and females individuals were obtained from Tanta University Hospital ,Tanta, Egypt were classified into four equal groups (5 individuals each) as follows: Group I: Healthy volunteers. Group II: NHL patients before chemotherapy; Group III: NHL patients after 4 cycles chemotherapy; Group IV: NHL patients after 6 cycles chemotherapy. WBCs were isolated from blood of all groups . Gene expression levels of ( IL-6 – IL-8 – TNF – IL-12A and IL-12B ) were analyzed by Gene Array Technology. The gene expression levels of IL-6 , IL-8 and TNF showed significant increases in patients before chemotherapy and after 4 and 6 cycles chemotherapy than healthy control, however IL-12A gene expression in NHL patients showed no significance change as compared With healthy controls . It could be concluded that NHL increased the expression levels of IL-6 , IL-8 and TNF that chemotherapy alters the expression levels of IL-6 and IL-8 but not TNF.
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