El-Sayed, H. (2024). Heterocyclization of α-aminonicotinonitrile: A new approach for synthesis of triazolo[1,5-a]pyridine-8-carbonitrile. Bulletin of Faculty of Science, Zagazig University, 2023(4), 49-54. doi: 10.21608/bfszu.2023.196730.1253
Hassan A El-Sayed. "Heterocyclization of α-aminonicotinonitrile: A new approach for synthesis of triazolo[1,5-a]pyridine-8-carbonitrile". Bulletin of Faculty of Science, Zagazig University, 2023, 4, 2024, 49-54. doi: 10.21608/bfszu.2023.196730.1253
El-Sayed, H. (2024). 'Heterocyclization of α-aminonicotinonitrile: A new approach for synthesis of triazolo[1,5-a]pyridine-8-carbonitrile', Bulletin of Faculty of Science, Zagazig University, 2023(4), pp. 49-54. doi: 10.21608/bfszu.2023.196730.1253
El-Sayed, H. Heterocyclization of α-aminonicotinonitrile: A new approach for synthesis of triazolo[1,5-a]pyridine-8-carbonitrile. Bulletin of Faculty of Science, Zagazig University, 2024; 2023(4): 49-54. doi: 10.21608/bfszu.2023.196730.1253
Heterocyclization of α-aminonicotinonitrile: A new approach for synthesis of triazolo[1,5-a]pyridine-8-carbonitrile
Department of Chemistry, Faculty of Science, Zagazig University,
Abstract
A new series of 1,2,4-triazolo[1,5-a]pyridine and pyrido[1,2-b]triazine was synthesized. The synthesis commenced with one-pot synthesis of pyran from 4-chlorobenzaldehyde, acetyl acetone and malononitrile in the presence of piperidine. The pyran 1 undergo ring transformation to pyridine derivatives 2 and 3 via reaction with amm.acetate and hydrazine hydrate. 1-Aminopyridine intermolecular cyclized to a new triazolo[1,5-a]pyridines 4-7 via reaction with acetic anhydride, carbon disulfide, formic acid and triethyl orthoformate. The triazine 8 was synthesized via cyclization of pyridine 1 with acetyl acetone in the presence of pyridine.A new series of 1,2,4-triazolo[1,5-a]pyridine and pyrido[1,2-b]triazine was synthesized. The synthesis commenced with one-pot synthesis of pyran from 4-chlorobenzaldehyde, acetyl acetone and malononitrile in the presence of piperidine. The pyran 1 undergo ring transformation to pyridine derivatives 2 and 3 via reaction with amm.acetate and hydrazine hydrate. 1-Aminopyridine intermolecular cyclized to a new triazolo[1,5-a]pyridines 4-7 via reaction with acetic anhydride, carbon disulfide, formic acid and triethyl orthoformate. The triazine 8 was synthesized via cyclization of pyridine 1 with acetyl acetone in the presence of pyridine.
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