Innovative strategies for biotechnological production of hyaluronic acid from different sources

Saed, Safaa; Askora, Ahmed; Enan, Gamal; Ahmed, Rania

doi:10.21608/bfszu.2023.198824.1260

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	Innovative strategies for biotechnological production of hyaluronic acid from different sources
Article 3, Volume 2023, Issue 4, January 2024, Page 35-48 PDF (1.34 MB)
Document Type: Original Article
DOI: 10.21608/bfszu.2023.198824.1260
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Authors
safaa Saed¹; Ahmed Askora ²; Gamal enan³; Rania Ahmed¹
¹1Department of Botany and Microbiology, Faculty of Science, Zagazig University 44511, Zagazig Egypt.
²Botany and microbiology department,Faculty of science,Zagazig University
³Faculty of science zagazig university
Abstract
Hyaluronic acid (HA) is a biological macromolecule belongs to a class of polysaccharides called glycosaminoglycans/mucopolysaccharides, a linear polysaccharide consist of repeating disaccharide unites. In the healthcare and pharmaceutical industries, HA has a wide range of uses. It is used in a variety of medical applications such as osteoarthritis (OA) treatment, cancer treatment, ophthalmology (aiding in eye surgery), wound healing, ageing processes, cosmetics and tissue engineering applications. HA has also recently been investigated as a drug delivery agent for a variety of routes including nasal, oral, pulmonary, ocular, topical and parenteral. HA can be produced by different methods such as physical, chemical and biological methods. Microorganisms have been used to produce HA, and this process has long been researched. The production of HA is enhanced by genetic engineering technique and optimizing the nutritional and environmental parameters of the fermentation medium. The aim of this review is to high light on the different strategies for HA production
Keywords
HA; Microorganisms; Medical; Application
Main Subjects
Basic and applied research of Microbiology


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