A series of pyridazino[3,4-d][1,3]oxazin-5-one derivatives were designed and synthesized through a versatile method. Reaction of chloro-ester 1 with sodium azide has afforded azido-ester 2 which reacted with triphenylphosphine to produce compound 3; amino-ester 4 was formed upon treatment of compound 3 with acetic acid 80%; this amino-ester 4 was then hydrolyzed to the amino-acid 5 which is considered the starting material. The approach involves treatment of pyridazinamino-acid 5 with acetic anhydride, benzoyl chloride, triethylorthoformate, ethyl chloroformate, diethyl oxalate, phthalic anhydride as well as succinic anhydride to yield pyridazino[3,4-d][1,3]oxazin-5-one derivatives 6, 8, 9, 10, 11, 12 and 13. The new synthesized compounds were confirmed by their infrared, mass spectrum and 1H-NMR.
Deeb, A., Hataba, A., El‐Eraky, W., & Abdel-Naby, H. (2017). PYRIDAZINE AND ITS RELATED COMPOUNDS, SYNTHESIS OF SOME NOVEL CONDENSED PYRIDAZINES. Bulletin of Faculty of Science, Zagazig University, 2017(1), 367-378. doi: 10.21608/bfszu.2017.31061
MLA
Ali Deeb; Ahmed Hataba; Wafaa El‐Eraky; Hend Abdel-Naby. "PYRIDAZINE AND ITS RELATED COMPOUNDS, SYNTHESIS OF SOME NOVEL CONDENSED PYRIDAZINES", Bulletin of Faculty of Science, Zagazig University, 2017, 1, 2017, 367-378. doi: 10.21608/bfszu.2017.31061
HARVARD
Deeb, A., Hataba, A., El‐Eraky, W., Abdel-Naby, H. (2017). 'PYRIDAZINE AND ITS RELATED COMPOUNDS, SYNTHESIS OF SOME NOVEL CONDENSED PYRIDAZINES', Bulletin of Faculty of Science, Zagazig University, 2017(1), pp. 367-378. doi: 10.21608/bfszu.2017.31061
VANCOUVER
Deeb, A., Hataba, A., El‐Eraky, W., Abdel-Naby, H. PYRIDAZINE AND ITS RELATED COMPOUNDS, SYNTHESIS OF SOME NOVEL CONDENSED PYRIDAZINES. Bulletin of Faculty of Science, Zagazig University, 2017; 2017(1): 367-378. doi: 10.21608/bfszu.2017.31061
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