Y. Moustafa, H., A. Younis, M., M. Azab, M. (2017). SYNTHESIS AND CYCLIZATION OF SOME THIOSEMICARBAZIDE DERIVATIVES. Bulletin of Faculty of Science, Zagazig University, 2017(1), 149-167. doi: 10.21608/bfszu.2017.31048
Hamed Y. Moustafa; Mohammed A. Younis; Mohammed M. Azab. "SYNTHESIS AND CYCLIZATION OF SOME THIOSEMICARBAZIDE DERIVATIVES". Bulletin of Faculty of Science, Zagazig University, 2017, 1, 2017, 149-167. doi: 10.21608/bfszu.2017.31048
Y. Moustafa, H., A. Younis, M., M. Azab, M. (2017). 'SYNTHESIS AND CYCLIZATION OF SOME THIOSEMICARBAZIDE DERIVATIVES', Bulletin of Faculty of Science, Zagazig University, 2017(1), pp. 149-167. doi: 10.21608/bfszu.2017.31048
Y. Moustafa, H., A. Younis, M., M. Azab, M. SYNTHESIS AND CYCLIZATION OF SOME THIOSEMICARBAZIDE DERIVATIVES. Bulletin of Faculty of Science, Zagazig University, 2017; 2017(1): 149-167. doi: 10.21608/bfszu.2017.31048
SYNTHESIS AND CYCLIZATION OF SOME THIOSEMICARBAZIDE DERIVATIVES
1Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
2Department of Chemistry, Faculty of Science, Banha Universty, Banha, Egypt
Abstract
The thiosemicarbazide 3 was obtained from reaction between hydrazine 2 and heteroallene 1. The condensed triazotriazole derivative 5 was obtained from the reaction of compound 3 with diethyl malonate. The cyclization of thiourea unit of compound 3 by heteroallene 1 furnished triazine 8. Benzoylation of compound 3 using benzoyl chloride 9 formed triazole derivative 11. Reaction of compound 3 and maleic anhydride 12 gave furothiadiazine 13. cyclohexanopyrimidinthione 16 was obtained as a result of cyclocondensation of cyclohexanone 14 with compound 3. Triazole 19 obtained from compound 3 and ammonium isothiocyanate 17 under thermal condition. Reaction of compound 3 with ethyl bromoacetate gave thiazole derivative 22. [2+3] cyclocondensation of acetyl acetone 23 and compound 3 provided pyrazole 25. Triazolotriazole 27 obtained from Formalin 26 and compound 3. Compound 3 suffers intramolecular base mediated cyclization affording triazole 28. Keeping compound 3 and propinaldehyde 29 under reflux provided triazolotriazole 31. Compound 3 oxidized by iodine to oxadiazole 32. Acylation of compound 3 by succinic acid formed triazolthione 34.