elsayed, D. (2023). Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of novel Azo-compounds derivatives as Significant Antioxidants. Bulletin of Faculty of Science, Zagazig University, 2023(1), 1-9. doi: 10.21608/bfszu.2022.156522.1168
doaa atef elsayed. "Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of novel Azo-compounds derivatives as Significant Antioxidants". Bulletin of Faculty of Science, Zagazig University, 2023, 1, 2023, 1-9. doi: 10.21608/bfszu.2022.156522.1168
elsayed, D. (2023). 'Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of novel Azo-compounds derivatives as Significant Antioxidants', Bulletin of Faculty of Science, Zagazig University, 2023(1), pp. 1-9. doi: 10.21608/bfszu.2022.156522.1168
elsayed, D. Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of novel Azo-compounds derivatives as Significant Antioxidants. Bulletin of Faculty of Science, Zagazig University, 2023; 2023(1): 1-9. doi: 10.21608/bfszu.2022.156522.1168
Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of novel Azo-compounds derivatives as Significant Antioxidants
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig , Egypt;
Abstract
ABASTRACT : due to azo compounds' diverse and intriguing bioactive characteristics, By combining two moles of diazonium salt with one mole of acetylacetone in an alkaline media, it is possible to create azo compounds, such as 2,2'-((2,4-dioxopentane-3,3-diyl)bis(diazene-2,1-diyl)dibenzoic acid. An excellent yield has been achieved in the development and production of several novel diazine and triazine compound derivative products. IR, 1H- NMR, 13C- NMR, and mass spectra were used to examine the composites' structural details. Using the [DPPH] approach, the goods' pharmaceutical activities as antioxidant activity was evaluated. The investigations have amply shown that compound 4 has positive antioxidant effects compared with vitamin C (IC50 = 22.90 μg/mL) as reference. The computational chemistry program MOE (2015) was used to investigate molecular docking for antioxidant activity, using reference substance produced from the cytochrome c peroxidase enzyme, in the database's molecular docking study to investigate the proposed mode of action (PDB code : 2X08, resolution : 2.01).
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