Carvone Hypoglycemic and Hypolipidemic effects by regulation of key proteins involved in fatty acid beta-oxidation in alloxan-induced diabetic rats.

Zein, Nabila; Shehata, Marwa Mohamed; Amer, Atef Mohamed

doi:10.21608/bfszu.2022.145262.1151

Carvone Hypoglycemic and Hypolipidemic effects by regulation of key proteins involved in fatty acid beta-oxidation in alloxan-induced diabetic rats.

Document Type : Original Article

Authors

¹ 18/mandoor street /Zagazig/Sharkia

² biochemistry,faculty of science,zagazig university

³ organic Chemistry Division, Chemistry Department, Faculty of Science, Zagazig University

10.21608/bfszu.2022.145262.1151

Abstract

Background: Essential oils are natural products with various biological characteristics caused by monoterpenes which have a high probability of producing new drugs Carvone, a monoterpenes has hypolipidemic, anti-inflammatory, hypoglycemic and antioxidant effects . Aim. The aim of this research is to show that carvone has medicinal potential in the treatment of diabetes and hyperlipidemia in alloxan-induced diabetic rats, as well as its effect on insulin activity. Material and methods .Four groups of male albino rats were formed, each with eight rats. In Group 1, healthy rats were provided a standard chow diet and were not given any medications. To develop diabetes, the rats in the other three groups were given a single intraperitoneal administration of alloxan (120 mg/kg), followed by a two-week feeding of an atherogenic hypercholesterolemic diet. The diabetic hyperlipidemic control (DHC) group received no treatment, while the other two groups received carvone (50 mg/kg) daily for one month and a combination drug (atorvastatin 10 mg/kg and metformin100 mg/kg) daily for one month, respectively. Results: our findings a reduction in the levels of blood glucose, cholesterol, triglyceride, LDL, fatty acid desaturase -1(FADS-1) , glucose-6-phosphate catalase -1(G6PC-1) and increase in the level of insulin and Acyle-co-A oxidase -1(ACOX-1) upon administration of carvone, Immunohistochemical investigation and results agree with biochemical indicators to some extent. Conclusion: carvone has anti-diabetic and anti-hyperlipidemia properties in diabetic hyperlipidemic rats by controlling essential proteins involved in fatty acid beta-oxidation (ACOX-1)

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