Metwally, W., Abdel Hamid, A., Assy, M., Abd El-Azim, M. (2022). Novel synthesis of Some Novel Pyrimidine Heterocycles.. Bulletin of Faculty of Science, Zagazig University, 2022(2), 101-104. doi: 10.21608/bfszu.2022.134859.1129
Wael Farid Metwally; Atef Mohamed Abdel Hamid; Mohamed G. Assy; Mohamed Abd El-Azim. "Novel synthesis of Some Novel Pyrimidine Heterocycles.". Bulletin of Faculty of Science, Zagazig University, 2022, 2, 2022, 101-104. doi: 10.21608/bfszu.2022.134859.1129
Metwally, W., Abdel Hamid, A., Assy, M., Abd El-Azim, M. (2022). 'Novel synthesis of Some Novel Pyrimidine Heterocycles.', Bulletin of Faculty of Science, Zagazig University, 2022(2), pp. 101-104. doi: 10.21608/bfszu.2022.134859.1129
Metwally, W., Abdel Hamid, A., Assy, M., Abd El-Azim, M. Novel synthesis of Some Novel Pyrimidine Heterocycles.. Bulletin of Faculty of Science, Zagazig University, 2022; 2022(2): 101-104. doi: 10.21608/bfszu.2022.134859.1129
Novel synthesis of Some Novel Pyrimidine Heterocycles.
2Department of chemistry, Faculty of science, Zagazig university
3Chemistry Dep., Faculty of Science, Zagazig University, Zagazig, Egypt
4Department of chemistry, faculty of science, Zagazig university
Abstract
The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools. The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools. The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools.
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