Novel synthesis of Some Novel Pyrimidine Heterocycles.

Document Type : Original Article

Authors

1 chemistry,science,zagazig

2 Department of chemistry, Faculty of science, Zagazig university

3 Chemistry Dep., Faculty of Science, Zagazig University, Zagazig, Egypt

4 Department of chemistry, faculty of science, Zagazig university

Abstract

The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools.
The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools.
The utilization of thioxouracil 1 as a precursor for the synthesis of some novel functionalized and annulated azines was reported here, thus amination of compound 1 afforded diaminopyrimidine scaffold 3 which upon treatment with benzoyl isothiocyanate furnished functionalized pyrimidine 5. Also, diazotization of 3 yielded tetrazolopyrimidine 7. The structures of the newly synthesized compounds were confirmed by different spectral tools.

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