soliman, M. (2020). 99mTc-Ibandronate as Imaging Radiopharmaceutical for Early Detection of Bone Diseases. Bulletin of Faculty of Science, Zagazig University, (), -. doi: 10.21608/bfszu.2020.37131.1032
mohammed salah soliman. "99mTc-Ibandronate as Imaging Radiopharmaceutical for Early Detection of Bone Diseases". Bulletin of Faculty of Science, Zagazig University, , , 2020, -. doi: 10.21608/bfszu.2020.37131.1032
soliman, M. (2020). '99mTc-Ibandronate as Imaging Radiopharmaceutical for Early Detection of Bone Diseases', Bulletin of Faculty of Science, Zagazig University, (), pp. -. doi: 10.21608/bfszu.2020.37131.1032
soliman, M. 99mTc-Ibandronate as Imaging Radiopharmaceutical for Early Detection of Bone Diseases. Bulletin of Faculty of Science, Zagazig University, 2020; (): -. doi: 10.21608/bfszu.2020.37131.1032
99mTc-Ibandronate as Imaging Radiopharmaceutical for Early Detection of Bone Diseases
Articles in Press, Accepted Manuscript, Available Online from 17 October 2020
Chemistry department, faculty of science, Helwan university
Abstract
Ibandronate was successfully labeled by using technetium-99m with maximum radiochemical yield (98.6%). The process is achieved by adding (25 µg) from stannous chloride in addition to (300 µg) of Ibandronate at room temperature in pH=7 for 15 min., we obtain a radiochemical yield (98.6%) and the radiolabeled complex was purified by high performance liquid chromatography (HPLC). The radiochemical yield was affected by many factors such as: Ibandronate amount, stannous chloride amount, reaction time, temperature of the reaction and pH of the reaction mixture. The in-vitro stability of 99mTc-Ibandronate was determined along (8 hours). The data obtained approve that 99mTc-Ibandronate complex was stable along (6 hours) without detection of any by-products in the reaction mixture. Biodistribution study showed high uptake and long retention of 99mTc-Ibandronate in bone was (44.32 % ID/organ) at (1 hour) post injection. Thus, 99mTc–Ibandronate could be used as a selective potential imaging agent for diagnosis of bone diseases